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Bone Formation Exceeds Bone Resorption In Osteoporosis. This leads imperceptibly into osteoporosis which most observers arbitrarily define as a reduction in bone mass that exceeds 30 of the average bone mass. Bone remodeling process and osteoporosis During growth bone is formed in the necessary places and resorbed as needed to attain the final shape in a process called modeling. The clinical consequences namely osteoporosis and fragility fractures are common and costly problems. Both excess resorption and excess formation takes place.
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Bone formation exceeds bone resorption in young adults. When the rate of bone resorption exceeds that of bone formation destruction of bone tissue occurs resulting in a fragile skeleton. The condition increases bone fragility and the risk of bone fracture is high. This fragile bone tissue and can lead to fractures. Bone resorption is the unique function of the osteoclast and anti-osteoporosis therapy to date has targeted this cell. Bone formation however rarely keeps up with excess bone resorption so a high turnover of bone remodeling often results in rapid.
During aging bone resorption begins to exceed bone formation.
Bone formation and resorption are ongoing phenomena. Common chronic metabolic bone disorder resulting in low bone density. Another interpretation of these data is that theanabolic effectofteriparatide ismaximal early during treatment when formation is increased and resorption is not. Bone formation exceeds bone resorption in young adults. While such bone mineral density assessments do not entirely account for a complete assessment of fracture risk they do indicate that significant osteoporosis can develop only if there is a net loss of bone mass. Occurs when rate of bone resorption osteoclast cells exceed the rate of bone formation osteoblasts.
2 AMS Circle Bethesda MD 20892-3676 Phone. In about the second decade bone mass increases with age. Both excess resorption and excess formation takes place. Bone formation exceeds bone resorption in young adults. Antiresorptive agents slow bone turnover and possibly allow bone formation to exceed bone resorption while anabolic agents directly stimulate bone formation and therefore enhance bone turnover.
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